General Information

  • ID:  hor005424
  • Uniprot ID:  P01330
  • Protein name:  Insulin A chain
  • Gene name:  INS
  • Organism:  Myocastor coypus (Coypu) (Nutria)
  • Family:  insulin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Myocastor (genus), Myocastoridae (family), Hystricomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GIVDQCCTNICSRNQLMSYCND
  • Length:  22(30-51)
  • Propeptide:  YVSQRLCGSQLVDTLYSVCRHRGFYRPNDGIVDQCCTNICSRNQLMSYCND
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45819
  • Structure ID:  AF-P01330-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005424_AF2.pdbhor005424_ESM.pdb

Physical Information

Mass: 285558 Formula: C97H158N30O36S5
Absent amino acids: AEFHKPW Common amino acids: C
pI: 4.11 Basic residues: 1
Polar residues: 12 Hydrophobic residues: 4
Hydrophobicity: -18.64 Boman Index: -4566
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 66.36
Instability Index: 5043.64 Extinction Coefficient cystines: 1740
Absorbance 280nm: 82.86

Literature

  • PubMed ID:  3541911
  • Title:  Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin.